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Recombinant Human G-CSF
名稱 Recombinant Human G-CSF
型號
更新時間 2023-09-24
特點 g - csf的造血生長因子刺激承諾祖細胞中性粒細胞的發展和增強的功能活動end-cell成熟。產生針對特定的刺激多種細胞包括巨噬細胞、成纖維細胞、內皮細胞和骨髓基質。使用g - csf臨床上促進骨髓移植后造血恢復。}
  • 詳細內容

一.產品名稱:Recombinant Human G-CSF

二.Catalog Number:300-23

Synonyms:

Granulocyte Colony-Stimulating Factor, CSF-3, MGI-1G, GM-CSF beta, pluripoietin

Description:

G-CSF is a hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It is produced in response to specific stimulation by a variety of cells including macrophages, fibroblasts, endothelial cells and bone marrow stroma. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation. Human and murine G-CSF are cross-species reactive. Recombinant human G-CSF is an 18.7 kDa protein consisting of 174 amino acid residues.

AA Sequence:

TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA LQEKLCATYK LCHPEELVLL GHSLGIPWAP LSSCPSQALQ LAGCLSQLHS GLFLYQGLLQ ALEGISPELG PTLDTLQLDV ADFATTIW MEELGMAPAL QPTQGAMPAF ASAFQRRAGG VLVASHLQSF LEVSYRVLRH LAQP

Source:

E.coli

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

The ED50 as determined by the dose-dependent stimulation of the proliferation of murine NFS-60 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.

Cross Reactivity:

Monkey, Mouse, Pig, Human, Plant

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