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名稱	Recombinant Human Heregulinβ-1
型號
更新時間	2023-09-24
特點	Neuregulin / Heregulin家庭結構相關的多肽生長因子來自或者基因(NRG1、NRG2 NRG3和NRG4)。迄今為止,有超過14可溶性和跨膜蛋白來自NRG1基因。heterodimerization erb2,激發內在的激酶活性,從而導致酪氨酸磷酸化。重組體人Heregulin-β1(HRG1-B1)是7.5 kDa多肽組成的只有EGF Heregulin-β1。}

詳細內容

一.產品名稱：Recombinant Human Heregulinβ-1

二.Catalog Number:AF-100-03

三.Synonyms:Neuregulin1 (NRG1-β1), Neu differentiation factor (rat)

四.Description:

Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms release soluble growth factors. HRG1-β1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity, which leads to tyrosine phosphorylation. Although HRG1-β1 biological effects is still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant human Heregulin-β1 (HRG1-B1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulin-β1 (65 amino acid residues). Manufactured using all non-animal reagents.

五.AA Sequence:

SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:

The ED₅₀ was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 10⁶ units/mg.

九.Cross Reactivity:Rat, Human, Mouse